A number of epidemiological studies of persons occupationally exposed to acrylonitrile have found excess cancers of the colon, prostate, and respiratory system, and … All implied warranties of merchantability and fitness for a particular purpose or use are hereby excluded. * Exposure to Acrylonitrile can cause weakness, headache, dizziness, confusion, nausea, vomiting, and can lead to death. Overview. The substance may cause effects on the central nervous system. Key words: Acrylonitrile, Carcinogenicity, Acute health effects, Chronic health effects, Occupational exposure limit Introduction Acrylonitrile (AN) is a colorless and volatile liquid with the boiling point of 77.3°C. C) EPIDEMIOLOGY: Exposures are uncommon, but deaths have been reported. ... failed to detect any health effect attributable to AN. A number of epidemiological studies of persons occupationally exposed to acrylonitrile have found excess cancers of the colon, prostate, and respiratory system, and excess deaths from lymphatic, stomach, and lung cancer. The major uses of acrylonitrile are in the manufacture of polymers, resins, plastics and nitrile rubbers. Registry (ATSDR). Note: Javascript is disabled or is not supported by your browser. It may also be used when there is inadequate evidence of carcinogenicity in humans but there is sufficient evidence of carcinogenicity in experimental animals. Sections I (Health Hazard Assessments for Noncarcinogenic Effects… For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry. Acrylonitrile can also be absorbed through the skin in quantities sufficient to cause adverse health effects. Acrylonitrile: health effects, incident management and toxicology Information on acrylonitrile (2-propenenitrile; cyanoethylene; vinyl cyanide) for … Acrylonitrile forms adducts with biological macromolecules. Acrylonitrile is a SUSPECTED HUMAN CARCINOGEN. 1) MILD TO MODERATE TOXICITY: Nausea, vomiting, diarrhea, sneezing, eye irritation, headache, weakness, and irritability may occur with mild to moderate exposures. 888-232-6348 (TTY) B) Acrylonitrile is a SUSPECTED HUMAN CARCINOGEN. The report summarizes and evaluates information relevant to a preliminary interim assessment of adverse health effects associated with specific chemicals or compounds. EPA has calculated an oral cancer slope factor of 0.54 (mg/kg/d)-1. Nitrogen oxides removed from effluent gas by scrubbers and/or thermal devices. The burning material releases fumes of hydrogen cyanide and oxides of nitrogen. Acrylonitrile (CASRN 107-13-1), also known as AN or vinyl cyanide, is a man-made VOC. Programme, the International Labour Organization, or the World Health Organization. recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. Acrylonitrile Fact Sheet. Effects also depend on the health of a person or the condition of the environment when exposure occurs. Concise International Chemical Assessment Document 39 ACRYLONITRILE Please note that the layout and pagination of this pdf file are not necessarily identital to those of the printed copy First draft prepared by G. Long and M.E. This category is used for agents, mixtures and exposure circumstances for which there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals. 1990. Health effects. The six factories were classified into three groups on the basis of AN concentration at workplaces. A) Acrylonitrile is carcinogenic in laboratory animals. • N-2-cyanoethylvaline (CEV) in blood and cotinine in urine were also determined.In non-smokers, a dose-response relation was observed between CEV and short-term health effects. Effects of short-term exposure The substance and the vapour are irritating to the eyes, skin and respiratory tract. A) DNA damage, unscheduled DNA synthesis, mutations, chromosome aberrations, sister chromatid exchanges, oncogenic transformation, and other genetic effects have been induced in a variety of short-term assay systems. C) The US Environmental Protection Agency classified it in Group B1 (probable human carcinogen), based on increased lung cancer in exposed workers and tumors in two strains of rats exposed by more than one route (IRIS , 1996). These products are provided "as is" and "as available" for use, without warranties of any kind, either express or implied. It also functions as a pesticide fumigant. It undergoes explosive polymerization. These clinics specialize in Profile for acrylonitrile, Toxicological The study subjects were 157 AN-exposed male shift workers who had been exposed to AN for 17 years on the average and 537 control workers whose working conditions were similar to those of the AN-exposed workers. [failed verification] ABS is amorphous and therefore has no true melting point.ABS is a terpolymer made by polymerizing styrene and acrylonitrile in the presence of polybutadiene. For this reason, some items on this page will be unavailable. 1.3 How can acrylonitrile enter and leave my body? 1.4 How can acrylonitrile affect my health? The relationship between the degree of exposure and biological effects of acrylonitrile (AN) was studied in 102 workers whose exposure period exceeded five years, and in 62 matched controls, all of whom had been randomly sampled from six acrylic fibre factories in Japan. profile for acrylonitrile, Agency for Toxic Substances and Disease Registry. However, acrylonitrile is metabolized to a lesser extent in humans than in rodents; therefore cyanide toxicity may play a lesser role in humans than toxicity of the parent compound or its more proximate metabolites. Exposure to acrylonitrile is primarily occupational: it is used in the manufacture of acrylic acid and modacrylic fibers. (C 3 H 3 N) z) is a common thermoplastic polymer. This fact sheet is part of a series of chemical fact sheets developed by TURI to help Massachusetts companies, community organizations and residents understand the chemical's use and health and environmental effects, as well as the availability of safer alternatives. Much of the toxicity of acrylonitrile is thought to be due to metabolic generation of cyanide; symptoms are similar to those induced by cyanide, but with slower onset. In Evaluation of Short-Term Toxicological 1.6 Is there a medical test to determine whether I have been exposed to acrylonitrile? Email: Contact CDC-INFO. Evidence of carcinogenicity in humans is limited. Route of occupational exposure The primary route of acrylonitrile exposure is via inhalation, with an average respiratory retention of 52 per cent. Potential health effects following exposure to acrylonitrile 4. B) TOXICOLOGY: Acrylonitrile can be toxic by the inhalation, ingestion, and dermal exposure routes. Hence, In conclusion the effects of acrylonitrile on human health and the environment depend on how much acrylonitrile is present and the length and frequency of exposure. ATSDR can also tell you the location of occupational and environmental health clinics. Agency for Toxic Substances and Disease Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. Acrylonitrile and derivatives, such as 2-chloro-acrylonitrile, are dienophiles in Diels-Alder reactions. ----- EPA Report No.560/7-81-007 July 1981 ENVIRONMENTAL AND HEALTH ASPECTS OF ACRYLONITRILE A Comprehensive Bibliography of Published Literature 1930 - 1981 by Management Support Division Information Support Services Branch Office of Toxic Substances Washington, D.C. 20460 68-06-5836 Project Officers Michael Weaver, Delores Evans Management Support Division … IRIS assessment development process. Its glass transition temperature is approximately 105 °C (221 °F). 5. Acrylonitrile is toxic by all routes, is readily absorbed and causes systemic toxicity in addition to local toxicity [1]. Adducts with human globin have been detected in the blood of exposed workers and of cigarette smokers. Dermal contact may result in erythema, dermatitis, a burning sensation, and blister formation. Global Health Humans Maximum Allowable Concentration Mice Neoplasms / chemically induced* Neoplasms / epidemiology Neoplasms, Experimental / … (focussing on health effects and mode of action of carcinogenicity) and of registration dossiers on acrylonitrile provided under the European chemicals legislation REACH9 (focussing on uses and workers’ exposure). Acrylonitrile (CAS 107-13-1) is a clear, colourless, highly flammable liquid with a mild, unpleasant odour. Immediately Dangerous to Life or Health Concentrations (IDLH) CAS number: 107-13-1 NIOSH REL: 1 ppm TWA, 10 ppm 15-minute CEILING [skin]; NIOSH considers acrylonitrile to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. Through the skin so that it may also be absorbed through the skin so that it may and... Damage the skin so that it may also be used when there is inadequate evidence of carcinogenicity experimental... 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